NRG Oncology/GOG Studies
- The purpose of this study was to assess the prognostic significance of a simplified, clinically accessible classification system for endometrioid endometrial cancers combining Lynch syndrome screening and molecular risk stratification.
- Endometrial cancer (EC) is responsible for ~76,000 deaths worldwide and has a higher incidence in developed countries due to its association with obesity . The majority of ECs are detected early (75%) and have a relatively good prognosis. However, if a patient presents with metastatic disease, or recurs after initial surgery, their prognosis is very poor, with a median survival of 7–12 months . Although the endometrioid histological subtype is associated with good prognosis compared to other subtypes, due to its prevalence it is still responsible for ~50% of all EC deaths.
- To determine the association between timing of adjuvant therapy initiation and survival of early stage ovarian cancer patients.
- Few studies have analyzed relationships between risk factors for endometrial cancer, especially with regard to aggressive (non-endometrioid) histologic subtypes, and prognosis. We examined these relationships in the prospective NRG Oncology/Gynecologic Oncology Group 210 trial.