This year the American Society of Clinical Oncology (ASCO) Annual Meeting took place from June 2–6, 2017 again in Chicago, Illinois. The theme for this year's meeting was: Making a difference in Cancer Care with YOU. This statement set the tone for a meeting focusing on the personalization of cancer care both by biomarker driven trials and targeted therapies. It represented a celebration of the collaboration among cancer caregivers, physicians, NPs, PAs, RNs and families. Delivering on this theme, the main plenary session contained papers on a large metanalysis in colorectal cancer, phase III studies in targeted therapy for prostate cancer and breast cancer plus a novel patient reported outcome process that improved overall survival (OS) across cancer subtypes.