- •Adjuvant radiotherapy after surgery improves overall survival for node-positive vulvar cancer patients aged 65 and older.
- •For node-positive vulvar cancer patients aged 85 and older, adjuvant radiotherapy provides no survival benefit.
- •A multidisciplinary and geriatrics-based approach best informs treatment for elderly node-positive vulvar cancer patients.
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- Trends in the incidence of invasive and in situ vulvar carcinoma.Obstet. Gynecol. 2006; 107: 1018-1022https://doi.org/10.1097/01.AOG.0000210268.57527.a1
- Trends in incidence and survival of women with invasive vulvar cancer in the United States and Canada: a population-based study.Gynecol. Oncol. 2014; 134: 314-318https://doi.org/10.1016/j.ygyno.2014.05.014
- Age-associated trends of vulvar cancer in the US.Menopause. 2021; 28: 119-125https://doi.org/10.1097/GME.0000000000001687
- Prognostic role of lymph node metastases in vulvar cancer and implications for adjuvant treatment.Int. J. Gynecol. Cancer. 2012; 22: 503-508https://doi.org/10.1097/IGC.0b013e31823eed4c
- Radiotherapy versus Inguinofemoral lymphadenectomy as treatment for vulvar Cancer patients with micrometastases in the sentinel node: results of GROINSS-V II.JCO. 2021; 39: 3623-3632https://doi.org/10.1200/JCO.21.00006
- Radiation therapy versus pelvic node resection for carcinoma of the vulva with positive groin nodes.Obstet. Gynecol. 1986; 68: 733-740
- Radiation therapy compared with pelvic node resection for node-positive vulvar cancer: a randomized controlled trial.Obstet. Gynecol. 2009; 114: 537-546https://doi.org/10.1097/AOG.0b013e3181b12f99
- Adjuvant therapy in lymph node–positive vulvar cancer: the AGO-CaRE-1 study.J. Natl. Cancer Inst. 2015; 107https://doi.org/10.1093/jnci/dju426
- Comparing national cancer registries: the National Cancer Data Base (NCDB) and the surveillance, epidemiology, and end results (SEER) program.J. Surg. Oncol. 2014; 109: 629-630https://doi.org/10.1002/jso.23568
- Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group.Stat. Med. 1998; 17: 2265-2281https://doi.org/10.1002/(sici)1097-0258(19981015)17:19<2265::aid-sim918>3.0.co;2-b
- An introduction to propensity score methods for reducing the effects of confounding in observational studies.Multivariate Behav Res. 2011; 46: 399-424https://doi.org/10.1080/00273171.2011.568786
- Understanding propensity score analyses.Int. J. Radiat. Oncol. Biol. Phys. 2020; 107: 404-407https://doi.org/10.1016/j.ijrobp.2020.02.638
- The central role of the propensity score in observational studies for causal effects.Biometrika. 1983; 70: 41-55https://doi.org/10.1093/biomet/70.1.41
- Challenges to delivery and effectiveness of adjuvant radiation therapy in elderly patients with node-positive vulvar cancer.Gynecol. Oncol. 2017; 146: 87-93https://doi.org/10.1016/j.ygyno.2017.05.004
- Strengths and limitations of large databases in lung cancer radiation oncology research.Translational Lung Cancer Research. 2019; 8 (Accessed January 29, 2022): S172-S183
- PRIME II investigators. Breast-conserving surgery with or without irradiation in women aged 65 years or older with early breast cancer (PRIME II): a randomised controlled trial.Lancet Oncol. 2015; 16: 266-273https://doi.org/10.1016/S1470-2045(14)71221-5
- Abstract GS2–03: Prime 2 randomised trial (postoperative radiotherapy in minimum-risk elderly): wide local excision and adjuvant hormonal therapy +/− whole breast irradiation in women >65 years with early invasive breast cancer: 10 year results.Cancer Res. 2021; 81 (GS2-GS2-03)https://doi.org/10.1158/1538-7445.SABCS20-GS2-03
- Lumpectomy plus tamoxifen with or without irradiation in women age 70 years or older with early breast cancer: long-term follow-up of CALGB 9343.J. Clin. Oncol. 2013; 31: 2382-2387https://doi.org/10.1200/JCO.2012.45.2615
- NCCN.(Accessed September 23, 2021)https://www.nccn.orgDate: 2022
- The use of adjuvant radiotherapy in elderly patients with early-stage breast cancer: changes in practice patterns after publication of Cancer and leukemia group B 9343.Cancer. 2015; 121: 188-193https://doi.org/10.1002/cncr.28937
- Healthcare utilization and costs during the initial phase of care among elderly women with breast cancer.J. Natl. Compr. Cancer Netw. 2017; 15: 1401-1409https://doi.org/10.6004/jnccn.2017.0167
- The evolving role of adjuvant radiotherapy for elderly women with early-stage breast cancer.Cancer. 2015; 121: 2331-2340https://doi.org/10.1002/cncr.29377
- Age and clinical decision making in oncology patients.J. Natl. Cancer Inst. 1994; 86: 1766-1770https://doi.org/10.1093/jnci/86.23.1766
- Validation of a prediction tool for chemotherapy toxicity in older adults with Cancer.J. Clin. Oncol. 2016; 34: 2366-2371https://doi.org/10.1200/JCO.2015.65.4327
- Evaluation of geriatric assessment and management on the toxic effects of cancer treatment (GAP70+): a cluster-randomised study.Lancet. 2021; 398: 1894-1904https://doi.org/10.1016/S0140-6736(21)01789-X
☆A portion of this work was previously presented in abstract form at the 2021 Annual Meeting of the American Society for Radiation Oncology.