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Immune checkpoint inhibitors in women with gynecologic cancers: Practical considerations

      Highlights

      • Currently, there are approved indications for immune checkpoint inhibitors in endometrial cancer and cervical cancer.
      • Pembrolizumab is approved for tumors with high microsatellite instability regardless of site of origin.
      • Toxicity of immune checkpoint inhibition are often autoimmune in nature, can occur early or late, and require vigilance.

      Abstract

      Immune checkpoint inhibitors are an exciting new class of cancer therapeutics. Recently, a PD-1 inhibitor has been approved by the Food and Drug Administration for several indications that are relevant to patients with gynecologic malignancies. In this review, we explore the clinical considerations for the use of checkpoint inhibitor therapy in this population. Specifically, we will discuss the approved indications, recommended dosing, clinical monitoring while on treatment, common adverse events, and treatment of adverse events should they arise. Additionally, we will review mechanisms of resistance and other challenges associated with the use of checkpoint inhibitors. We will conclude with a discussion of possible future directions for immunotherapy in women with gynecologic cancers.

      Keywords

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