Highlights
- •We report a cohort of 115 ovarian cancer patients treated with olaparib.
- •Median PFS was 12.7 months and median OS was 35.4 months, comparable to Study 19.
- •PFI ≥ 12 months, CR and normalized CA-125 are associated with prolonged PFS and OS
Abstract
Objective
To investigate clinical factors associated with prolonged progression-free survival
(PFS) and overall survival (OS) in relapsing epithelial ovarian cancer (EOC) patients
with BRCA mutations and receiving olaparib as maintenance therapy in daily practice.
Methods
Multicenter (8 hospitals) European retrospective study of relapsing EOC patients having
germline or somatic mutations of BRCA1/BRCA2 genes and treated with olaparib as maintenance therapy after platinum-based chemotherapy.
Results
One hundred and fifteen patients were included. Median age was 54 years. There were
90 BRCA1 carriers, 24 BRCA2 carriers and one patient had germline mutation of BRCA1 and BRCA2. Six patients had somatic mutations (all BRCA1) and 109 had germline mutations. Ninety percent had serous carcinomas and were platinum-sensitive.
Following ultimate platinum-based chemotherapy, 69% of the patients had normalization
of CA-125 levels and 87% had RECIST objective responses, either partial (53%) or complete
(34%). After a median follow-up of 21 months, median PFS was 12.7 months and median
OS was 35.4 months. In multivariate analysis, factors associated with prolonged PFS
under olaparib were: platinum-free interval (PFI) ≥ 12 months, RECIST complete response
(CR) or partial response (PR) and normalization of CA-125 upon ultimate platinum-based
chemotherapy. Factors associated with prolonged OS were PFI ≥ 12 months, CR and normalization
of CA-125.
Conclusions
Platinum-free interval ≥ 12 months, complete response and normalized CA-125 levels
after ultimate platinum-based chemotherapy are associated with prolonged PFS and OS
in relapsing BRCA1/BRCA2 mutated ovarian cancer patients who received olaparib as maintenance therapy.
Keywords
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Article info
Publication history
Published online: October 08, 2019
Accepted:
September 8,
2019
Received in revised form:
August 5,
2019
Received:
May 15,
2019
Identification
Copyright
© 2019 Elsevier Inc. All rights reserved.
