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Shaping the standard of care in ovarian cancer management: A review of Gynecologic Oncology Group (GOG)/NRG oncology clinical trials of the past twenty years

      Highlights

      • The GOG/NRG Oncology has led the evolution of ovarian cancer treatment through clinical trials.
      • The GOG/NRG Oncology has adapted to the changing landscape of cancer therapy.
      • Active GOG/NRG Oncology trials may radically change the paradigm of how we treat ovarian cancer.

      Abstract

      The Gynecologic Oncology Group (GOG), now part of the NRG Oncology network since the re-alignment of the National Clinical Trials Network in 2014, has played a fundamental role in creating the standard of care for women with ovarian cancer. GOG/NRG Oncology has had a series of achievements that have contributed to how we treat this disease; the approval of bevacizumab in frontline therapy, defining the role of intraperitoneal chemotherapy, optimal chemotherapy for early stage disease and the role of surgery in primary and recurrent disease management. Going forward, GOG/NRG Oncology is positioned to meet the ever changing knowledge that we have about the molecular background of this disease and the expanding repertoire of drugs/interventions in development.

      Keywords

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