Highlights
- •Genetic testing should be offered for epithelial ovarian cancer, irrespective of age
- •No statistical differences in toxicity were observed with olaparib use by age
- •Trends towards more hematologic toxicity were observed with increasing age
Abstract
Objectives
The objective of this study was to determine the overall tolerability and toxicity
of olaparib capsules among older (≥65 years) patients with recurrent ovarian cancer treated on 8 completed prospective trials
of olaparib.
Methods
An ancillary data analysis of 398 patients with recurrent ovarian cancer enrolled
on eight prospective trials of olaparib capsules was performed. Patients aged 65 years and older were stratified into age groups by 5 year increments (ages 65–69, 70–74, ≥75 years) and compared to those <65. Analysis was restricted to those patients receiving the recommended treatment
dose of 400 mg PO b.i.d.
Results
Of the 398 patients included, 78 were ≥65 (age 65–69 n = 38, age 70–74 n = 23, age ≥ 75 n = 17). The majority of elderly patients were Caucasian (n = 2 Asian) and had received ≥5 prior lines of chemotherapy. In patients <65, 46.9% required dose reduction as compared to 44.7% of patients 65–69 years, 47.8% of patients 70–74 years, and 64.7% of patients ≥75 years (p = 0.62). In patients <65 years 41.2% required dose interruption, as compared to 50%, 43.5%, and 64.7% of patients
aged 65–69, 70–74, and ≥75, respectively (p = 0.11). There were no occurrences of myelodysplastic syndrome or acute myeloid leukemia
in any of the older cohorts. Toxicities, including grade 3/4 nausea, were similar
across age groups.
Conclusions
Tolerability and toxicity of olaparib capsules is similar between women ≥65 years and <65 years of age treated for advanced recurrent ovarian cancer. Use of olaparib should
be considered in this patient population.
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Article info
Publication history
Published online: October 13, 2017
Accepted:
October 3,
2017
Received in revised form:
October 1,
2017
Received:
September 2,
2017
Identification
Copyright
© 2017 Elsevier Inc. All rights reserved.
