Highlights
- •In this cohort, 5.4% of asymptomatic BRCA mutation carriers had occult carcinomas in risk-reducing surgery specimens.
- •Patients with STIC had a higher incidence of subsequent serous cancer than those with benign adnexa.
- •The optimal postoperative management of patients with occult STIC lesions is unknown.
Abstract
Objective
To report the frequency and features of occult carcinomas and the incidence of subsequent
cancers following risk-reducing salpingo-oophorectomy (RRSO) in BRCA mutation carriers.
Methods
257 consecutive women with germline BRCA mutations who underwent RRSO between January 1, 2000 and December 31, 2014 were identified
in an Institutional Review Board approved study. All patients were asymptomatic with
normal physical exams, CA 125 values, and imaging studies preoperatively, and had
at least 12 months of follow-up post-RRSO. All patients had comprehensive adnexal sectioning performed.
Patient demographics and clinico-pathologic characteristics were extracted from medical
and pathology records.
Results
The cohort included 148 BRCA1, 98 BRCA2, 6 BRCA not otherwise specified (NOS), and 5 BRCA1 and 2 mutation carriers. Occult carcinoma was seen in 14/257 (5.4%) of patients: 9 serous
tubal intraepithelial carcinomas (STIC), 3 tubal cancers, 1 ovarian cancer, and 1
endometrial cancer. Three patients (1.2%) with negative pathology at RRSO subsequently
developed primary peritoneal serous carcinoma (PPSC), and 2 of 9 patients (22%) with
STIC subsequently developed pelvic serous carcinoma. 110 women (43%) were diagnosed
with breast cancer prior to RRSO, and 14 of the remaining 147 (9.5%) developed breast
cancer following RRSO. Median follow-up of the cohort was 63 months.
Conclusion
In this cohort, 5.4% of asymptomatic BRCA mutation carriers had occult carcinomas at RRSO, 86% of which were tubal in origin.
The risk of subsequent PPSC for women with benign adnexa at RRSO is low; however,
the risk of pelvic serous carcinoma among women with STIC is significantly higher.
Keywords
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Article info
Publication history
Published online: September 09, 2016
Accepted:
August 31,
2016
Received in revised form:
August 24,
2016
Received:
July 28,
2016
Identification
Copyright
© 2016 Published by Elsevier Inc.
