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Genomic testing and precision medicine — What does this mean for gynecologic oncology?

Published:December 04, 2015DOI:https://doi.org/10.1016/j.ygyno.2015.12.001
      Anti-cancer therapy based on pre-selection of cancers and patients through genomically characterized and identified molecular biomarkers has seen dramatic improvements in the treatment for breast cancer, lung cancer, certain leukemias and other malignancies. For gynecologic cancers, precision medicine through genomic testing has advanced the identification of high risk individuals as well as the treatment of specific types of ovarian cancer, i.e. germline BRCA mutated (gBRCAm), but has yet to significantly affect the standard treatment of BRCA wild type (BRCAwt) ovarian cancer, cervical or endometrial cancer. Nonetheless, the genomic characterization of gynecologic malignancies has provided the foundation for improved understanding of pathogenesis of gynecologic cancers, treatment advances, and outcome prediction for women with gynecologic cancers and is certain to have profound impact in the future.
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