151 — Featured Poster Session| Volume 137, SUPPLEMENT 1, 65, April 2015

Dietary isothiocyanates inhibit cancer cell growth by inducing replication stress mediated DNA damage response

      Objectives: Dietary Isothiocyanates (ITCs) such as allyl isothiocyanate (AITC) and phenyl isothiocyanate (PITC) are abundant in many cruciferous vegetables such as mustard, cabbage, broccoli, and brussels sprouts. These metabolites are safe and highly bioavailable and data suggest that consumption of these plants containing ITCs may support chemoprevention in cancers by offering protection against carcinogens. Considering the need for novel therapeutic agents in ovarian cancer, our objective was to assess the tumor-specific growth inhibitory properties of dietary phytochemicals on ovarian cancer.
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