Tumor-derived serum exosomal microRNA as a novel biomarker for high-grade serous carcinoma

      Objectives: High-grade serous cancer (HGSC) is diagnosed at an advanced stage due to the lack of a reliable early detection biomarker. Exosomes are microvesicles, 50–100 nm in size, that form when endosomes fuse with cell membranes and are released into the extracellular space. Modern genomic technology allows researchers to isolate and interrogate circulating serum exosomes. We hypothesize that tumor-derived serum exosomes contain microRNAs (miRNAs) that can serve as novel biomarkers for HGSC.
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