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Objectives: High-grade serous cancer (HGSC) is diagnosed at an advanced stage due to the lack
of a reliable early detection biomarker. Exosomes are microvesicles, 50–100 nm in size, that form when endosomes fuse with cell membranes and are released into
the extracellular space. Modern genomic technology allows researchers to isolate and
interrogate circulating serum exosomes. We hypothesize that tumor-derived serum exosomes
contain microRNAs (miRNAs) that can serve as novel biomarkers for HGSC.
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