Objectives: Two insulin receptor (INSR) isoforms, (INSR-B) and a splice variant that signals for cell proliferation and survival (INSR-A), are expressed in ovarian cancer (OC) cell lines. Obesity and type 2 diabetes are more common in the African American (AA) population, but little is known about OC INSR isoform expression in this group of patients. We hypothesized that differential expression of INSR-A in OC from AA women could represent a therapeutic target in this population.
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© 2014 Published by Elsevier Inc.