224| Volume 125, SUPPLEMENT 1, S93-S94, March 2012

Insulin-like growth factor binding protein-4 (IGFBP-4) tumor and serum levels are increased across all stages of epithelial ovarian cancer

      Objective: The recent application of massively parallel sequencing technologies to cancer genomes and transcriptomes has allowed for unbiased and complete view of the global changes associated with tumor development. We therefore hypothesized that analysis of the complete transcriptomes of early and late stage papillary serous tumors could be used to provide a unique catalogue of transcripts encoding tumor-secreted proteins. In this manner, novel candidate serum biomarkers for the detection and surveillance of both early and late stage EOC could be identified.
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