Objective: The recent application of massively parallel sequencing technologies to cancer genomes and transcriptomes has allowed for unbiased and complete view of the global changes associated with tumor development. We therefore hypothesized that analysis of the complete transcriptomes of early and late stage papillary serous tumors could be used to provide a unique catalogue of transcripts encoding tumor-secreted proteins. In this manner, novel candidate serum biomarkers for the detection and surveillance of both early and late stage EOC could be identified.
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© 2011 Published by Elsevier Inc.