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Abstract
Skene's (periurethral) gland carcinoma is a rare neoplasm accounting for less than
0.003% of all genital tract malignancies in females. Generally, adenocarcinomas of
the female urethra are assumed to arise from the periurethral glands, the female homologue
of the prostate. A case of Skene's gland adenocarcinoma without mucosal urethral involvement
is presented. The histologic features of this tumor closely resembled those of prostatic
adenocarcinoma. In contrast, clear cell and columnar/mucinous variants of female urethral
adenocarcinomas have been described previously. Perhaps this signifies different biologic
processes in the development of Skene's/periurethral and urethral adenocarcinomas
in females. Additionally, we performed immunohistochemical staining that was reactive
for prostate-specific antigen (PSA). Preoperatively, the serum level of PSA was increased
and promptly decreased after surgical excision of the lesion. Therefore, preoperative
and postoperative monitoring of serum PSA titers in patients with adenocarcinomas
of the female urethra or periurethral glands (or both) should be considered.
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Copyright
© 1994 Academic Press. Published by Elsevier Inc. All rights reserved.
